The eIF2α kinase HRI triggers the autophagic clearance of cytosolic protein aggregates

Large cytosolic protein aggregates are removed by two main cellular processes, autophagy and the ubiquitin-proteasome system, and defective clearance of these protein aggregates results in proteotoxicity and cell death. Recently, we found that the eIF2α kinase heme-regulated inhibitory (HRI) induced...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Mukherjee, Tapas, Ramaglia, Valeria, Abdel-Nour, Mena, Bianchi, Athanasia A., Tsalikis, Jessica, Chau, Hien N., Kalia, Suneil K., Kalia, Lorraine V., Chen, Jane-Jane, Arnoult, Damien, Gommerman, Jennifer L., Philpott, Dana J., Girardin, Stephen E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948985/
https://ncbi.nlm.nih.gov/pubmed/33168630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014415
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