Isoginkgetin, a Natural Biflavonoid Proteasome Inhibitor, Sensitizes Cancer Cells to Apoptosis via Disruption of Lysosomal Homeostasis and Impaired Protein Clearance

Protein degradation pathways are critical for maintaining proper protein dynamics within the cell, and considerable efforts have been made toward the development of therapeutics targeting these catabolic processes. We report here that isoginkgetin, a naturally derived biflavonoid, sensitized cells u...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Tsalikis, Jessica, Abdel-Nour, Mena, Farahvash, Armin, Sorbara, Matthew T., Poon, Stephanie, Philpott, Dana J., Girardin, Stephen E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497994/
https://ncbi.nlm.nih.gov/pubmed/30910794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00489-18
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