Proteasome inhibition and oxidative reactions disrupt cellular homeostasis during heme stress

Dual control of cellular heme levels by extracellular scavenger proteins and degradation by heme oxygenases is essential in diseases associated with increased heme release. During severe hemolysis or rhabdomyolysis, uncontrolled heme exposure can cause acute kidney injury and endothelial cell damage...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Vallelian, F, Deuel, J W, Opitz, L, Schaer, C A, Puglia, M, Lönn, M, Engelsberger, W, Schauer, S, Karnaukhova, E, Spahn, D R, Stocker, R, Buehler, P W, Schaer, D J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356336/
https://ncbi.nlm.nih.gov/pubmed/25301065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2014.154
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