Hemoglobinuria-related acute kidney injury is driven by intrarenal oxidative reactions triggering a heme toxicity response

Intravascular hemolysis can result in hemoglobinuria with acute kidney injury. In this study we systematically explored two in vivo animal models and a related cell culture system to identify hemoglobinuria-triggered damage pathways. In models of stored blood transfusion and hemoglobin (Hb) exposure...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Deuel, J W, Schaer, C A, Boretti, F S, Opitz, L, Garcia-Rubio, I, Baek, J H, Spahn, D R, Buehler, P W, Schaer, D J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4816175/
https://ncbi.nlm.nih.gov/pubmed/26794659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.392
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