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Revisiting the putative role of heme as a trigger of inflammation

Activation of the innate immune system by free heme has been proposed as one of the principal consequences of cell‐free hemoglobin (Hb) exposure. Nonetheless, in the absence of infection, heme exposures within a hematoma, during hemolysis, or upon systemic administration of Hb (eg, as a Hb‐based oxy...

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Библиографические подробности
Опубликовано в: :Pharmacol Res Perspect
Главные авторы: Vallelian, Florence, Schaer, Christian A., Deuel, Jeremy W., Ingoglia, Giada, Humar, Rok, Buehler, Paul W., Schaer, Dominik J.
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2018
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5878102/
https://ncbi.nlm.nih.gov/pubmed/29610666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.392
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