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Revisiting the putative role of heme as a trigger of inflammation

Activation of the innate immune system by free heme has been proposed as one of the principal consequences of cell‐free hemoglobin (Hb) exposure. Nonetheless, in the absence of infection, heme exposures within a hematoma, during hemolysis, or upon systemic administration of Hb (eg, as a Hb‐based oxy...

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Detalhes bibliográficos
Publicado no:Pharmacol Res Perspect
Main Authors: Vallelian, Florence, Schaer, Christian A., Deuel, Jeremy W., Ingoglia, Giada, Humar, Rok, Buehler, Paul W., Schaer, Dominik J.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5878102/
https://ncbi.nlm.nih.gov/pubmed/29610666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.392
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