Agonistic Anti-CD40 Antibody Triggers an Acute Liver Crisis With Systemic Inflammation in Humanized Sickle Cell Disease Mice

Sickle cell disease (SCD) is an inherited hemolytic disorder, defined by a point mutation in the β-globin gene. Stress conditions such as infection, inflammation, dehydration, and hypoxia trigger erythrocyte sickling. Sickled red blood cells (RBCs) hemolyze more rapidly, show impaired deformability,...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Yalamanoglu, Ayla, Dubach, Irina L., Schulthess, Nadja, Ingoglia, Giada, Swindle, Delaney C., Humar, Rok, Schaer, Dominik J., Buehler, Paul W., Irwin, David C., Vallelian, Florence
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7982888/
https://ncbi.nlm.nih.gov/pubmed/33763072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.627944
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