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Isoginkgetin, a Natural Biflavonoid Proteasome Inhibitor, Sensitizes Cancer Cells to Apoptosis via Disruption of Lysosomal Homeostasis and Impaired Protein Clearance

Protein degradation pathways are critical for maintaining proper protein dynamics within the cell, and considerable efforts have been made toward the development of therapeutics targeting these catabolic processes. We report here that isoginkgetin, a naturally derived biflavonoid, sensitized cells u...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Mol Cell Biol
Κύριοι συγγραφείς: Tsalikis, Jessica, Abdel-Nour, Mena, Farahvash, Armin, Sorbara, Matthew T., Poon, Stephanie, Philpott, Dana J., Girardin, Stephen E.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Microbiology 2019
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497994/
https://ncbi.nlm.nih.gov/pubmed/30910794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00489-18
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