Disruption of CSF-1R signaling inhibits growth of AML with inv(16)

Human inv(16) AML cells express CSF-1R and are exposed to CSF-1 in vivo. Inhibition of CSF-1R signaling reduces viability of inv(16) AML cells in vitro and in therapeutic settings in humanized mice in vivo.

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Bibliografiske detaljer
Udgivet i:Blood Adv
Main Authors: Simonis, Alexander, Russkamp, Norman F., Mueller, Jan, Wilk, C. Matthias, Wildschut, Mattheus H. E., Myburgh, Renier, Wildner-Verhey van Wijk, Nicole, Mueller, Rouven, Balabanov, Stefan, Valk, Peter J. M., Theocharides, Alexandre P. A., Manz, Markus G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2021
Fag:
Stimulus Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7948293/
https://ncbi.nlm.nih.gov/pubmed/33651098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020003125
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