BRAF(V)(600E) or mutant MAP2K1 human CD34(+) cells establish Langerhans cell–like histiocytosis in immune-deficient mice

BRAF(V600E) or mutant MAP2K1 expression in human CB CD34(+) HSPCs lead to Langerhans cell–like histiocytosis in immune-deficient mice. BRAF(V600E)-expressing human CB CD34(+) HSPCs did not generate hairy cell leukemia in xenograft mouse models.

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Bibliografiske detaljer
Udgivet i:Blood Adv
Main Authors: Rafiei, Anahita, Wilk, C. Matthias, Helbling, Patrick M., Myburgh, Renier, Saito, Yasuyuki, Haralambieva, Eugenia, Soldini, Davide, Chakraborty, Rikhia, Merad, Miriam, Allen, Carl E., Nombela-Arrieta, Cesar, Manz, Markus G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2020
Fag:
Stimulus Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7556147/
https://ncbi.nlm.nih.gov/pubmed/33035332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020001926
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