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Evolutionary insights into coagulation factor IX Padua and other high-specific-activity variants
The high-specific-activity factor IX (FIX) variant Padua (R338L) is the most promising transgene for hemophilia B (HB) gene therapy. Although R338 is strongly conserved in mammalian evolution, amino acid substitutions at this position are underrepresented in HB databases. We therefore undertook a co...
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| 發表在: | Blood Adv |
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| Main Authors: | , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society of Hematology
2021
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7948292/ https://ncbi.nlm.nih.gov/pubmed/33656538 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000405 |
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