Competitive Antagonism of Etomidate Action by Diazepam: In Vitro GABA(A) Receptor and In Vivo Zebrafish Studies

BACKGROUND: Recent cryo-electron microscopic imaging studies have shown that in addition to binding to the classical extracellular benzodiazepine binding site of the α(1)β(3)γ(2L) γ-aminobutyric acid type A (GABA(A)) receptor, diazepam also binds to etomidate binding sites located in the transmembra...

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發表在:Anesthesiology
Main Authors: McGrath, Megan, Hoyt, Helen, Pence, Andrea, Jayakar, Selwyn S., Zhou, Xiaojuan, Forman, Stuart A., Cohen, Jonathan B., Miller, Keith W., Raines, Douglas E.
格式: Artigo
語言:Inglês
出版: 2020
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7944240/
https://ncbi.nlm.nih.gov/pubmed/32541553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000003403
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