Exogenous Alpha-Synuclein Evoked Parkin Downregulation Promotes Mitochondrial Dysfunction in Neuronal Cells. Implications for Parkinson’s Disease Pathology

Aberrant secretion and accumulation of α-synuclein (α-Syn) as well as the loss of parkin function are associated with the pathogenesis of Parkinson’s disease (PD). Our previous study suggested a functional interaction between those two proteins, showing that the extracellular α-Syn evoked post-trans...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Aging Neurosci
Prif Awduron: Wilkaniec, Anna, Lenkiewicz, Anna M., Babiec, Lidia, Murawska, Emilia, Jęśko, Henryk M., Cieślik, Magdalena, Culmsee, Carsten, Adamczyk, Agata
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2021
Pynciau:
Neuroscience
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7943853/
https://ncbi.nlm.nih.gov/pubmed/33716707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2021.591475
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