Exogenous Alpha-Synuclein Evoked Parkin Downregulation Promotes Mitochondrial Dysfunction in Neuronal Cells. Implications for Parkinson’s Disease Pathology

Aberrant secretion and accumulation of α-synuclein (α-Syn) as well as the loss of parkin function are associated with the pathogenesis of Parkinson’s disease (PD). Our previous study suggested a functional interaction between those two proteins, showing that the extracellular α-Syn evoked post-trans...

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Detalhes bibliográficos
Publicado no:Front Aging Neurosci
Main Authors: Wilkaniec, Anna, Lenkiewicz, Anna M., Babiec, Lidia, Murawska, Emilia, Jęśko, Henryk M., Cieślik, Magdalena, Culmsee, Carsten, Adamczyk, Agata
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7943853/
https://ncbi.nlm.nih.gov/pubmed/33716707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2021.591475
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