Disease-associated mutations in inositol 1,4,5-trisphosphate receptor subunits impair channel function

The inositol 1,4,5-trisphosphate (IP(3)) receptors (IP(3)Rs), which form tetrameric channels, play pivotal roles in regulating the spatiotemporal patterns of intracellular calcium signals. Mutations in IP(3)Rs have been increasingly associated with many debilitating human diseases such as ataxia, Gi...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Terry, Lara E., Alzayady, Kamil J., Wahl, Amanda M., Malik, Sundeep, Yule, David I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2021
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7939385/
https://ncbi.nlm.nih.gov/pubmed/33093175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015683
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