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Disease-associated mutations in inositol 1,4,5-trisphosphate receptor subunits impair channel function
The inositol 1,4,5-trisphosphate (IP(3)) receptors (IP(3)Rs), which form tetrameric channels, play pivotal roles in regulating the spatiotemporal patterns of intracellular calcium signals. Mutations in IP(3)Rs have been increasingly associated with many debilitating human diseases such as ataxia, Gi...
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| 出版年: | J Biol Chem |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Biochemistry and Molecular Biology
2021
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7939385/ https://ncbi.nlm.nih.gov/pubmed/33093175 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015683 |
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