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Disease-associated mutations in inositol 1,4,5-trisphosphate receptor subunits impair channel function

The inositol 1,4,5-trisphosphate (IP(3)) receptors (IP(3)Rs), which form tetrameric channels, play pivotal roles in regulating the spatiotemporal patterns of intracellular calcium signals. Mutations in IP(3)Rs have been increasingly associated with many debilitating human diseases such as ataxia, Gi...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Terry, Lara E., Alzayady, Kamil J., Wahl, Amanda M., Malik, Sundeep, Yule, David I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7939385/
https://ncbi.nlm.nih.gov/pubmed/33093175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015683
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