Fragmented Inositol 1,4,5-Trisphosphate Receptors Retain Tetrameric Architecture and Form Functional Ca(2+) Release Channels

Inositol 1,4,5-trisphosphate receptor isoforms are a family of ubiquitously expressed ligand-gated channels encoded by three individual genes. The proteins are localized to membranes of intracellular Ca(2+) stores and play pivotal roles in Ca(2+) homeostasis. Previous studies have demonstrated that...

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Bibliographic Details
Main Authors: Alzayady, Kamil J., Chandrasekhar, Rahul, Yule, David I.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630841/
https://ncbi.nlm.nih.gov/pubmed/23479737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.453241
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