Defining the Stoichiometry of Inositol 1,4,5-Trisphosphate Binding Required to Initiate Ca(2+) Release

Inositol 1,4,5-trisphosphate (IP(3)) receptors (IP(3)Rs) are tetrameric intracellular Ca(2+)-release channels with each subunit containing a binding site for IP(3) in the N-terminus. We provide evidence that four IP(3) molecules are required to activate the channel under diverse conditions. Comparin...

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Publicado en:Sci Signal
Main Authors: Alzayady, Kamil J., Wang, Liwei, Chandrasekhar, Rahul, Wagner, Larry E., Van Petegem, Filip, Yule, David I.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4850551/
https://ncbi.nlm.nih.gov/pubmed/27048566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aad6281
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