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Defining the Stoichiometry of Inositol 1,4,5-Trisphosphate Binding Required to Initiate Ca(2+) Release
Inositol 1,4,5-trisphosphate (IP(3)) receptors (IP(3)Rs) are tetrameric intracellular Ca(2+)-release channels with each subunit containing a binding site for IP(3) in the N-terminus. We provide evidence that four IP(3) molecules are required to activate the channel under diverse conditions. Comparin...
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| 出版年: | Sci Signal |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4850551/ https://ncbi.nlm.nih.gov/pubmed/27048566 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aad6281 |
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