Region-specific proteolysis differentially regulates type 1 inositol 1,4,5-trisphosphate receptor activity

The inositol 1,4,5 trisphosphate receptor (IP(3)R) is an intracellular Ca(2+) release channel expressed predominately on the membranes of the endoplasmic reticulum. IP(3)R1 can be cleaved by caspase or calpain into at least two receptor fragments. However, the functional consequences of receptor fra...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Wang, Liwei, Wagner, Larry E., Alzayady, Kamil J., Yule, David I.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5512067/
https://ncbi.nlm.nih.gov/pubmed/28526746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.789917
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