Comparative engraftment and clonality of macaque HSPCs expanded on human umbilical vein endothelial cells versus non-expanded cells

Ex vivo hematopoietic stem and progenitor cell (HSPC) expansion platforms are under active development, designed to increase HSPC numbers and thus engraftment ability of allogeneic cord blood grafts or autologous HSPCs for gene therapies. Murine and in vitro models have not correlated well with clin...

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Bibliographic Details
Published in:Mol Ther Methods Clin Dev
Main Authors: Srivastava, Sandeep K., Truitt, Lauren L., Wu, Chuanfeng, Glaser, Adam, Nolan, Daniel J., Ginsberg, Michael, Espinoza, Diego A., Koelle, Samson, Yabe, Idalia M., Yu, Kyung-Rok, Hong, Sogun, Sellers, Stephanie, Krouse, Allen, Bonifacino, Aylin, Metzger, Mark, Dagur, Pradeep K., Donahue, Robert E., Dunbar, Cynthia E., Panch, Sandhya R.
Format: Artigo
Language:Inglês
Published: American Society of Gene & Cell Therapy 2021
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7937567/
https://ncbi.nlm.nih.gov/pubmed/33738325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2021.02.009
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