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T Cell Exhaustion and CAR-T Immunotherapy in Hematological Malignancies

T cell exhaustion has been recognized to play an immunosuppressive role in malignant diseases. Persistent tumor antigen stimulation, the presence of inhibitory immune cells and cytokines in tumor microenvironment (TME), upregulated expression of inhibitory receptors, changes in T cell-related transc...

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Detalles Bibliográficos
Publicado en:Biomed Res Int
Main Authors: Tang, Lu, Zhang, Yinqiang, Hu, Yu, Mei, Heng
Formato: Artigo
Idioma:Inglês
Publicado: Hindawi 2021
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7936901/
https://ncbi.nlm.nih.gov/pubmed/33728333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2021/6616391
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