Discovery and characterization of bromodomain 2–specific inhibitors of BRDT

Bromodomain testis (BRDT), a member of the bromodomain and extraterminal (BET) subfamily that includes the cancer targets BRD2, BRD3, and BRD4, is a validated contraceptive target. All BET subfamily members have two tandem bromodomains (BD1 and BD2). Knockout mice lacking BRDT-BD1 or both bromodomai...

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Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Yu, Zhifeng, Ku, Angela F., Anglin, Justin L., Sharma, Rajesh, Ucisik, Melek Nihan, Faver, John C., Li, Feng, Nyshadham, Pranavanand, Simmons, Nicholas, Sharma, Kiran L., Nagarajan, Sureshbabu, Riehle, Kevin, Kaur, Gundeep, Sankaran, Banumathi, Storl-Desmond, Marta, Palmer, Stephen S., Young, Damian W., Kim, Choel, Matzuk, Martin M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2021
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7936271/
https://ncbi.nlm.nih.gov/pubmed/33637650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2021102118
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