Discovery and characterization of bromodomain 2–specific inhibitors of BRDT

Bromodomain testis (BRDT), a member of the bromodomain and extraterminal (BET) subfamily that includes the cancer targets BRD2, BRD3, and BRD4, is a validated contraceptive target. All BET subfamily members have two tandem bromodomains (BD1 and BD2). Knockout mice lacking BRDT-BD1 or both bromodomai...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Yu, Zhifeng, Ku, Angela F., Anglin, Justin L., Sharma, Rajesh, Ucisik, Melek Nihan, Faver, John C., Li, Feng, Nyshadham, Pranavanand, Simmons, Nicholas, Sharma, Kiran L., Nagarajan, Sureshbabu, Riehle, Kevin, Kaur, Gundeep, Sankaran, Banumathi, Storl-Desmond, Marta, Palmer, Stephen S., Young, Damian W., Kim, Choel, Matzuk, Martin M.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2021
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7936271/
https://ncbi.nlm.nih.gov/pubmed/33637650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2021102118
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