Epigenetic regulation of p62/SQSTM1 overcomes the radioresistance of head and neck cancer cells via autophagy-dependent senescence induction

Tumors are composed of subpopulations of cancer cells with functionally distinct features. Intratumoral heterogeneity limits the therapeutic effectiveness of cancer drugs. To address this issue, it is important to understand the regulatory mechanisms driving a subclonal variety within a therapy-resi...

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Veröffentlicht in:Cell Death Dis
Hauptverfasser: Lee, Myungjin, Nam, Hae Yun, Kang, Hee-Bum, Lee, Won Hyeok, Lee, Geun-Hee, Sung, Gi-Jun, Han, Myung Woul, Cho, Kyung-Ja, Chang, Eun-Ju, Choi, Kyung-Chul, Kim, Seong Who, Kim, Sang Yoon
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7935951/
https://ncbi.nlm.nih.gov/pubmed/33674559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-021-03539-5
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