Allosteric HIV integrase inhibitors promote formation of inactive branched polymers via homomeric carboxy-terminal domain interactions

The major effect of allosteric HIV integrase (IN) inhibitors (ALLINIs) is observed during virion maturation, where ALLINI treatment interrupts IN-RNA interactions via drug-induced IN aggregation, leading to the formation of aberrant virions. To understand the structural changes that accompany drug-i...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Structure
मुख्य लेखकों: Gupta, Kushol, Allen, Audrey, Giraldo, Carolina, Eilers, Grant, Sharp, Robert, Hwang, Young, Murali, Hemma, Cruz, Katrina, Janmey, Paul, Bushman, Frederic, Van Duyne, Gregory D.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2020
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC7935764/
https://ncbi.nlm.nih.gov/pubmed/33357410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2020.12.001
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