Allosteric Inhibition of Human Immunodeficiency Virus Integrase: LATE BLOCK DURING VIRAL REPLICATION AND ABNORMAL MULTIMERIZATION INVOLVING SPECIFIC PROTEIN DOMAINS

HIV-1 replication in the presence of antiviral agents results in evolution of drug-resistant variants, motivating the search for additional drug classes. Here we report studies of GSK1264, which was identified as a compound that disrupts the interaction between HIV-1 integrase (IN) and the cellular...

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Detalhes bibliográficos
Main Authors: Gupta, Kushol, Brady, Troy, Dyer, Benjamin M., Malani, Nirav, Hwang, Young, Male, Frances, Nolte, Robert T., Wang, Liping, Velthuisen, Emile, Jeffrey, Jerry, Van Duyne, Gregory D., Bushman, Frederic D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4110260/
https://ncbi.nlm.nih.gov/pubmed/24904063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.551119
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