Allosteric HIV integrase inhibitors promote formation of inactive branched polymers via homomeric carboxy-terminal domain interactions

The major effect of allosteric HIV integrase (IN) inhibitors (ALLINIs) is observed during virion maturation, where ALLINI treatment interrupts IN-RNA interactions via drug-induced IN aggregation, leading to the formation of aberrant virions. To understand the structural changes that accompany drug-i...

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Publicado no:Structure
Main Authors: Gupta, Kushol, Allen, Audrey, Giraldo, Carolina, Eilers, Grant, Sharp, Robert, Hwang, Young, Murali, Hemma, Cruz, Katrina, Janmey, Paul, Bushman, Frederic, Van Duyne, Gregory D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7935764/
https://ncbi.nlm.nih.gov/pubmed/33357410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2020.12.001
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