Prefusion structure of human cytomegalovirus glycoprotein B and structural basis for membrane fusion

Human cytomegalovirus (HCMV) causes congenital disease with long-term morbidity. HCMV glycoprotein B (gB) transitions irreversibly from a metastable prefusion to a stable postfusion conformation to fuse the viral envelope with a host cell membrane during entry. We stabilized prefusion gB on the viri...

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Publicat a:Sci Adv
Autors principals: Liu, Yuhang, Heim, Kyle P., Che, Ye, Chi, Xiaoyuan, Qiu, Xiayang, Han, Seungil, Dormitzer, Philip R., Yang, Xinzhen
Format: Artigo
Idioma:Inglês
Publicat: American Association for the Advancement of Science 2021
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7935361/
https://ncbi.nlm.nih.gov/pubmed/33674318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abf3178
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