Structural basis for immunization with postfusion respiratory syncytial virus fusion F glycoprotein (RSV F) to elicit high neutralizing antibody titers

Respiratory syncytial virus (RSV), the main cause of infant bronchiolitis, remains a major unmet vaccine need despite more than 40 years of vaccine research. Vaccine candidates based on a chief RSV neutralization antigen, the fusion (F) glycoprotein, have foundered due to problems with stability, pu...

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Detalhes bibliográficos
Main Authors: Swanson, Kurt A., Settembre, Ethan C., Shaw, Christine A., Dey, Antu K., Rappuoli, Rino, Mandl, Christian W., Dormitzer, Philip R., Carfi, Andrea
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3111287/
https://ncbi.nlm.nih.gov/pubmed/21586636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1106536108
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