Single-cell analyses identify circulating anti-tumor CD8 T cells and markers for their enrichment

The ability to monitor anti-tumor CD8(+) T cell responses in the blood has tremendous therapeutic potential. Here, we used paired single-cell RNA and TCR sequencing to detect and characterize “tumor-matching” (TM) CD8(+) T cells in the blood of mice with MC38 tumors or melanoma patients using the TC...

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Publicat a:J Exp Med
Autors principals: Pauken, Kristen E., Shahid, Osmaan, Lagattuta, Kaitlyn A., Mahuron, Kelly M., Luber, Jacob M., Lowe, Margaret M., Huang, Linglin, Delaney, Conor, Long, Jaclyn M., Fung, Megan E., Newcomer, Kathleen, Tsai, Katy K., Chow, Melissa, Guinn, Samantha, Kuchroo, Juhi R., Burke, Kelly P., Schenkel, Jason M., Rosenblum, Michael D., Daud, Adil I., Sharpe, Arlene H., Singer, Meromit
Format: Artigo
Idioma:Inglês
Publicat: Rockefeller University Press 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7933992/
https://ncbi.nlm.nih.gov/pubmed/33651880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20200920
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