Single-cell analyses identify circulating anti-tumor CD8 T cells and markers for their enrichment

The ability to monitor anti-tumor CD8(+) T cell responses in the blood has tremendous therapeutic potential. Here, we used paired single-cell RNA and TCR sequencing to detect and characterize “tumor-matching” (TM) CD8(+) T cells in the blood of mice with MC38 tumors or melanoma patients using the TC...

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Pubblicato in:J Exp Med
Autori principali: Pauken, Kristen E., Shahid, Osmaan, Lagattuta, Kaitlyn A., Mahuron, Kelly M., Luber, Jacob M., Lowe, Margaret M., Huang, Linglin, Delaney, Conor, Long, Jaclyn M., Fung, Megan E., Newcomer, Kathleen, Tsai, Katy K., Chow, Melissa, Guinn, Samantha, Kuchroo, Juhi R., Burke, Kelly P., Schenkel, Jason M., Rosenblum, Michael D., Daud, Adil I., Sharpe, Arlene H., Singer, Meromit
Natura: Artigo
Lingua:Inglês
Pubblicazione: Rockefeller University Press 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7933992/
https://ncbi.nlm.nih.gov/pubmed/33651880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20200920
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