Elevated post-ischemic ubiquitination results from suppression of deubiquitinase activity and not proteasome inhibition

Cerebral ischemia–reperfusion increases intraneuronal levels of ubiquitinated proteins, but the factors driving ubiquitination and whether it results from altered proteostasis remain unclear. To address these questions, we used in vivo and in vitro models of cerebral ischemia–reperfusion, in which h...

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Bibliografiske detaljer
Udgivet i:Cell Mol Life Sci
Main Authors: Kahles, Timo, Poon, Carrie, Qian, Liping, Palfini, Victoria, Srinivasan, Shanmukha Priya, Swaminathan, Shilpa, Blanco, Ismary, Rodney-Sandy, Reunet, Iadecola, Costantino, Zhou, Ping, Hochrainer, Karin
Format: Artigo
Sprog:Inglês
Udgivet: Springer International Publishing 2020
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7933347/
https://ncbi.nlm.nih.gov/pubmed/32889561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-020-03625-5
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