Chromothripsis drives the evolution of gene amplification in cancer

Focal chromosomal amplification is an important route to generating cancer through mediating over-expression of oncogenes(1–3) or to developing cancer therapy resistance by increasing expression of a gene whose action diminishes efficacy of an anti-cancer drug. Here we used whole-genome sequencing o...

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Vydáno v:Nature
Hlavní autoři: Shoshani, Ofer, Brunner, Simon F., Yaeger, Rona, Ly, Peter, Nechemia-Arbely, Yael, Kim, Dong Hyun, Fang, Rongxin, Castillon, Guillaume A., Yu, Miao, Li, Julia S.Z., Sun, Ying, Ellisman, Mark H., Ren, Bing, Campbell, Peter J., Cleveland, Don W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7933129/
https://ncbi.nlm.nih.gov/pubmed/33361815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-03064-z
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