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DNA replication acts as an error correction mechanism to maintain centromere identity by restricting CENP-A to centromeres
Chromatin assembled with the histone H3 variant CENP-A is the heritable epigenetic determinant of human centromere identity. Using genome-wide mapping and reference models for 23 human centromeres, CENP-A binding sites are identified within the megabase-long, repetitive α-satellite DNAs at each cent...
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| Publicado no: | Nat Cell Biol |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7015266/ https://ncbi.nlm.nih.gov/pubmed/31160708 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-019-0331-4 |
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