DNA replication acts as an error correction mechanism to maintain centromere identity by restricting CENP-A to centromeres

Chromatin assembled with the histone H3 variant CENP-A is the heritable epigenetic determinant of human centromere identity. Using genome-wide mapping and reference models for 23 human centromeres, CENP-A binding sites are identified within the megabase-long, repetitive α-satellite DNAs at each cent...

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Vydáno v:Nat Cell Biol
Hlavní autoři: Nechemia-Arbely, Yael, Miga, Karen H., Shoshani, Ofer, Aslanian, Aaron, McMahon, Moira A., Lee, Ah Young, Fachinetti, Daniele, Yates, John R., Ren, Bing, Cleveland, Don W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7015266/
https://ncbi.nlm.nih.gov/pubmed/31160708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-019-0331-4
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