Chromosome Segregation Errors Generate a Diverse Spectrum of Simple and Complex Genomic Rearrangements

Cancer genomes are frequently characterized by numerical and structural chromosomal abnormalities. Here we integrated a centromere-specific inactivation approach with selection for a conditionally essential gene, a strategy termed ‘CEN-SELECT’, to systematically interrogate the structural landscape...

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Detalhes bibliográficos
Publicado no:Nat Genet
Main Authors: Ly, Peter, Brunner, Simon F., Shoshani, Ofer, Kim, Dong Hyun, Lan, Weijie, Pyntikova, Tatyana, Flanagan, Adrienne M., Behjati, Sam, Page, David C., Campbell, Peter J., Cleveland, Don W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6441390/
https://ncbi.nlm.nih.gov/pubmed/30833795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-019-0360-8
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