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Chromosome Segregation Errors Generate a Diverse Spectrum of Simple and Complex Genomic Rearrangements
Cancer genomes are frequently characterized by numerical and structural chromosomal abnormalities. Here we integrated a centromere-specific inactivation approach with selection for a conditionally essential gene, a strategy termed ‘CEN-SELECT’, to systematically interrogate the structural landscape...
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| Veröffentlicht in: | Nat Genet |
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| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6441390/ https://ncbi.nlm.nih.gov/pubmed/30833795 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-019-0360-8 |
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