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Multiple Myeloma Cells Alter Adipogenesis, Increase Senescence-Related and Inflammatory Gene Transcript Expression, and Alter Metabolism in Preadipocytes

Within the bone marrow microenvironment, mesenchymal stromal cells (MSCs) are an essential precursor to bone marrow adipocytes and osteoblasts. The balance between this progenitor pool and mature cells (adipocytes and osteoblasts) is often skewed by disease and aging. In multiple myeloma (MM), a can...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Fairfield, Heather, Costa, Samantha, Falank, Carolyne, Farrell, Mariah, Murphy, Connor S., D’Amico, Anastasia, Driscoll, Heather, Reagan, Michaela R.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7930573/
https://ncbi.nlm.nih.gov/pubmed/33680918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.584683
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