Myeloma-modified adipocytes exhibit metabolic dysfunction and a senescence-associated secretory phenotype (SASP)

Bone marrow adipocytes (BMAd) have recently been implicated in accelerating bone metastatic cancers such as acute myelogenous leukemia and breast cancer. Importantly, bone marrow adipose tissue (BMAT) expands with aging and obesity - two key risk factors in multiple myeloma disease prevalence - sugg...

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Pubblicato in:Cancer Res
Autori principali: Fairfield, Heather, Dudakovic, Amel, Khatib, Casper M., Farrell, Mariah, Costa, Samantha, Falank, Carolyne, Hinge, Maja, Murphy, Connor S., DeMambro, Victoria, Pettitt, Jessica A., Lary, Christine W., Driscoll, Heather E., McDonald, Michelle M., Kassem, Moustapha, Rosen, Clifford, Andersen, Thomas L., van Wijnen, Andre J., Jafari, Abbas, Reagan, Michaela R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7854508/
https://ncbi.nlm.nih.gov/pubmed/33218968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-1088
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