Myeloma-modified adipocytes exhibit metabolic dysfunction and a senescence-associated secretory phenotype (SASP)

Bone marrow adipocytes (BMAd) have recently been implicated in accelerating bone metastatic cancers such as acute myelogenous leukemia and breast cancer. Importantly, bone marrow adipose tissue (BMAT) expands with aging and obesity - two key risk factors in multiple myeloma disease prevalence - sugg...

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Bibliografiske detaljer
Udgivet i:Cancer Res
Main Authors: Fairfield, Heather, Dudakovic, Amel, Khatib, Casper M., Farrell, Mariah, Costa, Samantha, Falank, Carolyne, Hinge, Maja, Murphy, Connor S., DeMambro, Victoria, Pettitt, Jessica A., Lary, Christine W., Driscoll, Heather E., McDonald, Michelle M., Kassem, Moustapha, Rosen, Clifford, Andersen, Thomas L., van Wijnen, Andre J., Jafari, Abbas, Reagan, Michaela R.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7854508/
https://ncbi.nlm.nih.gov/pubmed/33218968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-1088
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