Myeloma-modified adipocytes exhibit metabolic dysfunction and a senescence-associated secretory phenotype (SASP)

Bone marrow adipocytes (BMAd) have recently been implicated in accelerating bone metastatic cancers such as acute myelogenous leukemia and breast cancer. Importantly, bone marrow adipose tissue (BMAT) expands with aging and obesity - two key risk factors in multiple myeloma disease prevalence - sugg...

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Veröffentlicht in:Cancer Res
Hauptverfasser: Fairfield, Heather, Dudakovic, Amel, Khatib, Casper M., Farrell, Mariah, Costa, Samantha, Falank, Carolyne, Hinge, Maja, Murphy, Connor S., DeMambro, Victoria, Pettitt, Jessica A., Lary, Christine W., Driscoll, Heather E., McDonald, Michelle M., Kassem, Moustapha, Rosen, Clifford, Andersen, Thomas L., van Wijnen, Andre J., Jafari, Abbas, Reagan, Michaela R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7854508/
https://ncbi.nlm.nih.gov/pubmed/33218968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-20-1088
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