CD73 Ectonucleotidase Restrains CD8+ T Cell Metabolic Fitness and Anti-tumoral Activity

CD39 and CD73 are ectoenzymes that dephosphorylate ATP into its metabolites; ADP, AMP, and adenosine, and thus are considered instrumental in the development of immunosuppressive microenvironments. We have previously shown that within the CD8+ T cell population, naïve and memory cells express the CD...

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Опубликовано в: :Front Cell Dev Biol
Главные авторы: Briceño, Pedro, Rivas-Yañez, Elizabeth, Rosemblatt, Mariana V., Parra-Tello, Brian, Farías, Paula, Vargas, Leonardo, Simon, Valeska, Cárdenas, César, Lladser, Alvaro, Salazar-Onfray, Flavio, Elorza, Alvaro A., Rosemblatt, Mario, Bono, María Rosa, Sauma, Daniela
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2021
Предметы:
Cell and Developmental Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7930398/
https://ncbi.nlm.nih.gov/pubmed/33681221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.638037
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