Exonuclease VII repairs quinolone-induced damage by resolving DNA gyrase cleavage complexes

The widely used quinolone antibiotics act by trapping prokaryotic type IIA topoisomerases, resulting in irreversible topoisomerase cleavage complexes (TOPcc). Whereas the excision repair pathways of TOPcc in eukaryotes have been extensively studied, it is not known whether equivalent repair pathways...

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Bibliografske podrobnosti
izdano v:Sci Adv
Main Authors: Huang, Shar-yin N., Michaels, Stephanie A., Mitchell, Brianna B., Majdalani, Nadim, Vanden Broeck, Arnaud, Canela, Andres, Tse-Dinh, Yuk-Ching, Lamour, Valerie, Pommier, Yves
Format: Artigo
Jezik:Inglês
Izdano: American Association for the Advancement of Science 2021
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7929499/
https://ncbi.nlm.nih.gov/pubmed/33658195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abe0384
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