Exonuclease VII repairs quinolone-induced damage by resolving DNA gyrase cleavage complexes

The widely used quinolone antibiotics act by trapping prokaryotic type IIA topoisomerases, resulting in irreversible topoisomerase cleavage complexes (TOPcc). Whereas the excision repair pathways of TOPcc in eukaryotes have been extensively studied, it is not known whether equivalent repair pathways...

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Detaylı Bibliyografya
Yayımlandı:Sci Adv
Asıl Yazarlar: Huang, Shar-yin N., Michaels, Stephanie A., Mitchell, Brianna B., Majdalani, Nadim, Vanden Broeck, Arnaud, Canela, Andres, Tse-Dinh, Yuk-Ching, Lamour, Valerie, Pommier, Yves
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Association for the Advancement of Science 2021
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7929499/
https://ncbi.nlm.nih.gov/pubmed/33658195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abe0384
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