Exonuclease VII repairs quinolone-induced damage by resolving DNA gyrase cleavage complexes

The widely used quinolone antibiotics act by trapping prokaryotic type IIA topoisomerases, resulting in irreversible topoisomerase cleavage complexes (TOPcc). Whereas the excision repair pathways of TOPcc in eukaryotes have been extensively studied, it is not known whether equivalent repair pathways...

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Publicat a:Sci Adv
Autors principals: Huang, Shar-yin N., Michaels, Stephanie A., Mitchell, Brianna B., Majdalani, Nadim, Vanden Broeck, Arnaud, Canela, Andres, Tse-Dinh, Yuk-Ching, Lamour, Valerie, Pommier, Yves
Format: Artigo
Idioma:Inglês
Publicat: American Association for the Advancement of Science 2021
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7929499/
https://ncbi.nlm.nih.gov/pubmed/33658195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abe0384
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