Mrc1-Dependent Chromatin Compaction Represses DNA Double-Stranded Break Repair by Homologous Recombination Upon Replication Stress

The coordination of DNA replication and repair is critical for the maintenance of genome stability. It has been shown that the Mrc1-mediated S phase checkpoint inhibits DNA double-stranded break (DSB) repair through homologous recombination (HR). How the replication checkpoint inhibits HR remains on...

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Detalhes bibliográficos
Publicado no:Front Cell Dev Biol
Main Authors: Xing, Poyuan, Dong, Yang, Zhao, Jingyu, Zhou, Zhou, Li, Zhao, Wang, Yu, Li, Mengfei, Zhang, Xinghua, Chen, Xuefeng
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7928320/
https://ncbi.nlm.nih.gov/pubmed/33681209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.630777
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