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Functional genomics screen identifies proteostasis targets that modulate prion protein (PrP) stability
Prion protein (PrP) adopts either a helical conformation (PrP(C)) or an alternative, beta sheet-rich, misfolded conformation (PrP(Sc)). The PrP(Sc) form has the ability to “infect” PrP(C) and force it into the misfolded state. Accumulation of PrP(Sc) is associated with a number of lethal neurodegene...
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| Vydáno v: | Cell Stress Chaperones |
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| Hlavní autoři: | , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Springer Netherlands
2021
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7925731/ https://ncbi.nlm.nih.gov/pubmed/33547632 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12192-021-01191-8 |
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