Selinexor versus doxorubicin in dedifferentiated liposarcoma PDXs: evidence of greater activity and apoptotic response dependent on p53 nuclear accumulation and survivin down‐regulation

BACKGROUND: Dedifferentiated liposarcoma (DDLPS), a tumor that lacks effective treatment strategies and is associated with poor outcomes, expresses amplified MDM2 in the presence of wild-type p53. MDM2 ubiquitination of p53 facilitates its XPO1-mediated nuclear export, thus limiting p53 tumor suppre...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:J Exp Clin Cancer Res
Auteurs principaux: Zuco, Valentina, Pasquali, Sandro, Tortoreto, Monica, Brich, Silvia, Percio, Stefano, Dagrada, Gian Paolo, Colombo, Chiara, Sanfilippo, Roberta, Lauricella, Calogero, Gounder, Mrinal, El Bezawy, Rihan, Barisella, Marta, Dei Tos, Angelo Paolo, Casali, Paolo Giovanni, Gronchi, Alessandro, Stacchiotti, Silvia, Zaffaroni, Nadia
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2021
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7923610/
https://ncbi.nlm.nih.gov/pubmed/33648535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-021-01886-x
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires