Selinexor versus doxorubicin in dedifferentiated liposarcoma PDXs: evidence of greater activity and apoptotic response dependent on p53 nuclear accumulation and survivin down‐regulation

BACKGROUND: Dedifferentiated liposarcoma (DDLPS), a tumor that lacks effective treatment strategies and is associated with poor outcomes, expresses amplified MDM2 in the presence of wild-type p53. MDM2 ubiquitination of p53 facilitates its XPO1-mediated nuclear export, thus limiting p53 tumor suppre...

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Detalhes bibliográficos
Publicado no:J Exp Clin Cancer Res
Main Authors: Zuco, Valentina, Pasquali, Sandro, Tortoreto, Monica, Brich, Silvia, Percio, Stefano, Dagrada, Gian Paolo, Colombo, Chiara, Sanfilippo, Roberta, Lauricella, Calogero, Gounder, Mrinal, El Bezawy, Rihan, Barisella, Marta, Dei Tos, Angelo Paolo, Casali, Paolo Giovanni, Gronchi, Alessandro, Stacchiotti, Silvia, Zaffaroni, Nadia
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7923610/
https://ncbi.nlm.nih.gov/pubmed/33648535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-021-01886-x
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