miR-34a-Mediated Survivin Inhibition Improves the Antitumor Activity of Selinexor in Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC) is an aggressive disease with limited therapeutic options. Here, we pursued a combinatorial therapeutic approach to enhance the activity of selinexor, the first-in-class XPO1 inhibitor, by miR-34a ectopic expression in human TNBC experimental models. Anti-prolife...

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Bibliographic Details
Published in:Pharmaceuticals (Basel)
Main Authors: Martini, Silvia, Zuco, Valentina, Tortoreto, Monica, Percio, Stefano, Campi, Elisa, El Bezawy, Rihan, Doldi, Valentina, Landesman, Yosef, Pennati, Marzia, Zaffaroni, Nadia
Format: Artigo
Language:Inglês
Published: MDPI 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8227962/
https://ncbi.nlm.nih.gov/pubmed/34072442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph14060523
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