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Bispecific antibodies with Fab-arms featuring exchanged antigen-binding constant domains

Monoclonal antibodies can acquire the property of engagement of a second antigen via fusion methods or modification of their CDR loops, but also by modification of their constant domains, such as in the mAb(2) format where a set of mutated amino acid residues in the C(H)3 domains enables a high-affi...

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Bibliografiske detaljer
Udgivet i:Biochem Biophys Rep
Main Authors: Benedetti, Filippo, Stracke, Florian, Stadlmayr, Gerhard, Stadlbauer, Katharina, Rüker, Florian, Wozniak-Knopp, Gordana
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7920882/
https://ncbi.nlm.nih.gov/pubmed/33718630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2021.100959
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