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Bispecific antibodies with Fab-arms featuring exchanged antigen-binding constant domains
Monoclonal antibodies can acquire the property of engagement of a second antigen via fusion methods or modification of their CDR loops, but also by modification of their constant domains, such as in the mAb(2) format where a set of mutated amino acid residues in the C(H)3 domains enables a high-affi...
Shranjeno v:
| izdano v: | Biochem Biophys Rep |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Elsevier
2021
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7920882/ https://ncbi.nlm.nih.gov/pubmed/33718630 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2021.100959 |
| Oznake: |
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