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Stabilization of the CD81 Large Extracellular Loop with De Novo Disulfide Bonds Improves Its Amenability for Peptide Grafting

Tetraspan proteins are significantly enriched in the membranes of exosomal vesicles (EVs) and their extracellular domains are attractive targets for engineering towards specific antigen recognition units. To enhance the tolerance of a tetraspanin fold to modification, we achieved significant thermal...

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Detalhes bibliográficos
Publicado no:Pharmaceutics
Main Authors: Vogt, Stefan, Stadlmayr, Gerhard, Stadlbauer, Katharina, Sádio, Flávio, Andorfer, Peter, Grillari, Johannes, Rüker, Florian, Wozniak-Knopp, Gordana
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6160918/
https://ncbi.nlm.nih.gov/pubmed/30150531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics10030138
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