Stabilization of soluble high‐affinity T‐cell receptor with de novo disulfide bonds

Soluble T‐cell receptors (TCRs) have recently gained visibility as target‐recognition units of anticancer immunotherapeutic agents. Here, we improved the thermal stability of the well‐expressed high‐affinity A6 TCR by introducing pairs of cysteines in the invariable parts of the α‐ and β‐chain. A mu...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:FEBS Lett
Prif Awduron: Sádio, Flávio, Stadlmayr, Gerhard, Stadlbauer, Katharina, Gräf, Maximilian, Scharrer, Agnes, Rüker, Florian, Wozniak‐Knopp, Gordana
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2019
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7027902/
https://ncbi.nlm.nih.gov/pubmed/31552676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.13616
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