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Stabilization of soluble high‐affinity T‐cell receptor with de novo disulfide bonds
Soluble T‐cell receptors (TCRs) have recently gained visibility as target‐recognition units of anticancer immunotherapeutic agents. Here, we improved the thermal stability of the well‐expressed high‐affinity A6 TCR by introducing pairs of cysteines in the invariable parts of the α‐ and β‐chain. A mu...
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| Publicado no: | FEBS Lett |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7027902/ https://ncbi.nlm.nih.gov/pubmed/31552676 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.13616 |
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