Stabilization of soluble high‐affinity T‐cell receptor with de novo disulfide bonds

Soluble T‐cell receptors (TCRs) have recently gained visibility as target‐recognition units of anticancer immunotherapeutic agents. Here, we improved the thermal stability of the well‐expressed high‐affinity A6 TCR by introducing pairs of cysteines in the invariable parts of the α‐ and β‐chain. A mu...

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Detaylı Bibliyografya
Yayımlandı:FEBS Lett
Asıl Yazarlar: Sádio, Flávio, Stadlmayr, Gerhard, Stadlbauer, Katharina, Gräf, Maximilian, Scharrer, Agnes, Rüker, Florian, Wozniak‐Knopp, Gordana
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2019
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7027902/
https://ncbi.nlm.nih.gov/pubmed/31552676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1873-3468.13616
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