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An antibody with Fab-constant domains exchanged for a pair of C(H)3 domains
We have designed a complete antibody-like construct where the C(H)1 and C(κ) domains are exchanged for a pair of the C(H)3 domains and efficient pairing of the heavy and light variable domain is achieved using “Knobs-into-Holes” strategy. This construct, composed of only naturally occurring immunogl...
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| Publicado no: | PLoS One |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5891013/ https://ncbi.nlm.nih.gov/pubmed/29630643 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0195442 |
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